As in all therapies - not all outcomes are equally favorable. In a small percentage of those who receive radiotherapy, the tissue response is accentuated and damage to normal tissue occurs. The unpleasant effects usually settle post irradiation, these effect can be eased by Hyperbaric Oxygen Therapy.

It is estimated that about 15% to 25% of people with diabetes develop a foot ulcer in their lifetime. These wounds are often resistant to treatment and difficult to heal; therefore, people with diabetes experience lower limb amputation at about 20 times the rate of people without diabetes. Hyperbaric Oxygen Therapy can improve this healing process, saving limbs.